Desparing
星期天, 一月 20, 2008

既然之前寫了一篇跟癌症相關的

那就順道把之前約略 整理 + 篩選 與 CoQ10 相關的東西一起放上來吧

剛好也是 整理 寫給我媽的....至於她有沒有看嘛... LOL 大概不會吧 (因為都是英文)

內容我都有讀過 並且已經篩選過的... 大多都是有真實證據 或是 大學/醫院 的研究報告 

反正有興趣的人 就自己讀吧  有問題也可以問我

個人是不打算翻譯那些內容的 ... 畢竟那又不是我的職業 我也賺不到錢 說了也未必有人聽 :)

寫了對整個 man kind 甚至於地球 也未必有幫助 

所以 自己讀吧!

 

CoQ10 根據某些來源指出

有降血壓 防癌 預防心臟病 甚至更多其他功能

題外話: milk thistle 則有幫助肝功能 甚至於 預防肝癌的可能性....有機會在貼

==============Use of CoQ10==============

Uses based on tradition or theory

Abnormal heart rhythms, amyotrophic lateral sclerosis (ALS), antioxidant, asthma, atherosclerosis, Bell's palsy, blood flow disorders, breathing difficulties, cancer, cerebellar ataxia, chronic fatigue syndrome, chronic obstructive pulmonary disease (COPD), deafness, gingivitis, hair loss (and hair loss from chemotherapy), heart irregular beats, hepatitis B, high cholesterol, immune system diseases, infertility, insomnia, kidney failure, leg swelling (edema), life extension, liver enlargement or disease, lung cancer, lung disease, macular degeneration, MELAS syndrome, metastatic disease, MIDD (maternally inherited diabetes mellitus and deafness), muscle wasting, nutrition, obesity, Papillon-Lefevre Syndrome, physical performance, prevention of muscle damage from "statin" cholesterol-lowering drugs, psychiatric disorders, QT-interval shortening; reduction of phenothiazine drug side effects, reduction of tricyclic antidepressant (TCA) drug side effects, stomach ulcer, swelling.

Source: Coenzyme Q10 @ MayoClinic.com
(The website also includes a list of detailed evidence and its credibility grading.)

===========Cancer Related================

Coenzyme Q 10 is a compound that is made naturally in the body. The body uses it for cell growth and to protect cells from damage that could lead to cancer.

Animal studies have shown that coenzyme Q10 helps the immune system work better and makes the body better able to resist certain infections and types of cancer.

Clinical trials have shown that coenzyme Q10  helps protect the heart from the damaging side effects of doxorubicin, a drug used to treat cancer.

In 3 small studies of coenzyme Q10 in breast cancer patients, some patients appeared to be helped by the treatment. Weaknesses in study design and reporting, however, made it unclear if benefits were caused by the coenzyme Q10 or by something else.

Coenzyme Q10 may not mix safely with other treatments. It is important that patients tell their health care providers about all therapies they are currently using or thinking of using.

Coenzyme Q10 has not been carefully tested to see if it is safe and effective. Because coenzyme Q10 is sold as a dietary supplement rather than a drug, it is not regulated by the US Food and Drug Administration.

Source: Coenzyme Q10 @ National Cancer Institute

===========================

CoQ10 @ Congestive Heart Failure patients ( CHFpatients.com)
(no evidence for improvement, however, sick hearts do have Less CoQ10)

===========================

Coenzyme Q10 may be indicated in cardiovascular disease, particularly in congestive heart failure. It may also be indicated to correct reduced blood levels of CoQ10 that result from the use of HMG-CoA reductase inhibitors used to treat elevated cholesterol levels. It also appears to have usefulness in the management of periodontal disease in some. There is far less evidence to support claims that it has positive effects in cancer, muscular dystrophy and immune dysfunction. Similarly, there is as yet no reliable evidence that it can inhibit obesity or enhance athletic performance.

Coenzyme Q10 (CoQ10) @ Physicians Desk Reference ( PDRhealth.com)

==============
Huntington's Disease ===============

In April 2006, veteran researcher R. Ferrante and collaborators reported results from a thorough and significant study of CoQ-10 "Dose ranging and efficacy study of high-dose coenzyme Q-10 formulations in Huntington's disease mice" (Biochem Biophys Acta. 2006 Apr 17)). In this article, the authors find that more is better. The HD mice treated with high dose CoQ-10 had survival benefit of 25.3%, which is significantly higher than 13-14.5% benefit shown in earlier studies using lower doses. (Ferrante 2002, 2005).

CoQ10: more is best @ the
Huntington's Disease light house

===============CoQ10's Use on Drug=================

specific coenzyme Q-10 products have been given orphan drug status in the United States. An orphan drug has received FDA approval because it shows effectiveness for treating severe or rare diseases that usually have few other treatment options.

In the United States, designated coenzyme Q10 products are used to treat Huntington's disease, childhood heart failure, and rare, inherited disorders of red blood cell formation or defects in mitochondria, which are tiny structures within body cells.

CoQ10 @ Drug Digest (use of CoQ10)

===================================

Scientists believe CoQ10 is an antioxidant (a compound that blocks activated oxygen molecules, known as free radicals, that can damage cells), and that it may also have an effect on the immune system. Some studies have suggested that deficiencies of CoQ10 may contribute to certain diseases such as cancer.

Coenzyme Q10 @ American Cancer Society (Breast Cancer)

Note: Information on Antioxidant & Free Radicals

===============History========
============

Coenzyme Q was first discovered by professor Fred L. Crane and colleagues at the University of Wisconsin-Madison Enzyme Institute in 1957. In 1958, its chemical structure was reported by Professor Karl Folkers and coworkers at Merck. For his discovery of the significant part played by CoQ10 in energy production, the British scientist Peter D. Mitchell was awarded the Nobel Prize for chemistry in 1978.

Coenzyme Q10 @ Wikipedia (General Information)

===================================

Introduction to Coenzyme Q10  By PETER H. LANGSJOEN, M.D., F.A.C.C.

================================

Information on CoQ10 (Researches) @ University of Washington (General Information)

John T. A. Ely had included 19 selected PubMed research abstracts.
Abstract Titles :
Effective and safe therapy with coenzyme Q10 for cardiomyopathy.
    --
Clinical responses on therapy with CoQ10 appear maximal with blood levels of approx. 2.5 micrograms CoQ10/ml and higher during therapy.

Response of patients in classes III and IV of cardiomyopathy to therapy in a blind and crossover trial with coenzyme Q10.
    --
These patients, steadily worsening and expected to die within 2 years under conventional therapy, generally showed an extraordinary clinical improvement, indicating that CoQ10 therapy might extend the lives of such patients.This improvement could be due to correction of a myocardial deficiency of CoQ10 and to enhanced synthesis of CoQ10-requiring enzymes.

Effective treatment with coenzyme Q10 of patients with chronic myocardial disease.
    --
Eighteen patients reported improvement in activity tolerance with oral CoQ10 replacement therapy.

Therapy with coenzyme Q10 of patients in heart failure who are eligible or ineligible for a transplant.
   --
The marked improvement is based upon correcting myocardial deficiencies of CoQ10 which improve mitochondrial bioenergetics and cardiac performance.

A six-year clinical study of therapy of cardiomyopathy with coenzyme Q10.
   --
One hundred and forty-three cases of chronic, stable, non- secondary, non-hypertrophic cardiomyopathy were given 100 mg of coenzyme Q10** orally in addition to their conventional medical programme in an open-label long-term study. Survival figures were encouraging with an 11.1% mortality in 12 months and 17.8% mortality in 24 months.

Pronounced increase of survival of patients with cardiomyopathy when treated with coenzyme Q10 and conventional therapy.
   --
The improved cardiac function and pronounced increase of survival show that therapy with CoQ10 is remarkably beneficial due to correction of CoQ10 deficiency in mechanisms of bioenergetics.

Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases.
   --
The numerous metastases in the liver of a 44-year-old patient "disappeared," and no signs of metastases were found elsewhere. A 49-year-old patient, on a dosage of 390 mg of vitamin Q10, revealed no signs of tumor in the pleural cavity after six months, and her condition was excellent. A 75-year-old patient with carcinoma in one breast, after lumpectomy and 390 mg of CoQ10, showed no cancer in the tumor bed or metastases. Control blood levels of CoQ10 of 0.83-0.97 and of 0.62 micrograms/ml increased to 3.34-3.64 and to 3.77 micrograms/ml, respectively, on therapy with CoQ10 for patients A-MRH and EEL.

Apparent partial remission of breast cancer in 'high risk' patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10.
  --

Partial and complete regression of breast cancer in patients in relation to dosage of coenzyme Q10.
The activities of coenzyme Q10 and vitamin B6 for immune responses.
Survival of cancer patients on therapy with coenzyme Q10.
Survival effect of coenzyme Q10 and naloxone on experimental stroke gerbils.
Possible use of coenzyme Q10 in acute cerebral disease.
Hemorrhagic Stroke in Human Pretreated with Coenzyme Q10: Exceptional Recovery as Seen in Animal Models.
Overview of the use of CoQ10 in cardiovascular disease.
Lethal Candidiasis: An Interpretive Review with Emphasis on Neglected, Safe, Effective, Inexpensive Therapies
A brief update on ubiquinone (Coenzyme Q10).
Does gastrointestinal Candida albicans prevent ubiquinone absorption?


=================================

Possible Health Benefits of Coenzyme Q10 @ Oregon State University (General Information)

Study Suggests Coenzyme Q10 Slows Functional Decline in Parkinson's Disease @ National Institute of Neurological Disorders and Stroke (Parkinson's Disease)

Small Doses of Coenzyme Q10 Does Not Improve Parkinson's Disease Symptoms @ ScienceDaily.com

 

rural 發表於 8:26 AM | 靜態連結 | 迴響留言 | 引用列表 | 觀看 (21351)

日前收到一封我媽寄給我的轉寄信件

內容不外乎 是關於癌症的資訊 寫這種信是好的 可是內容也必須要是正確的阿

這封信原本出自於 英文版
大概是有所謂 "好心人" 想說把資訊翻譯成中文 傳出去
可是卻連內容都沒有驗證

John Hopkins 的聲明

內容大約是說
關於癌症細胞資訊的信 並不是由 John Hopkins 所發出
關於微波容器的信 也不是由 John Hopkins 所發出

========================================== 
另外則是 關於 Dioxin (戴奧辛)

Johns Hopkins 也做出了相關說明

http://www.jhsph.edu/dioxins 

在該說明文中並寫了 

Freezing water does not cause the release of chemicals from plastic bottles.
(將水冷凍並不會造成塑膠水瓶釋放化學物質到水裡) 

 

 John Hopkins 也針對相關文章 發出了一個文章

標題為 研究人員破除"戴奧辛與塑膠水瓶的迷思"

Researcher Dispels Myth of Dioxins and Plastic Water Bottles

Addition information about dioxins and water bottles

========================

又另, 該信內容 有些關於 癌症知識 有少數的正確性

不過在相信之前 應該要約略查證一下

以下是個人的查證與回應

http://www.thedietchannel.com/Cancer-and-Diet-Does-Sugar-Feed-Cancer.htm

Simple sugars enter the bloodstream quickly and cause a rise in insulin and other growth-promoting hormones. Research shows that high levels of these hormones may increase the growth of cancer cells. The key to reducing these hormones is reducing your intake of simple sugars. Complex carbohydrates do not affect insulin the same as simple sugars, and thousands of research studies have shown that they actually reduce the risk of cancer.

===============

http://www.nutritionj.com/content/3/1/19

Glucose Metabolism

Refined sugar is a high energy, low nutrient food – junk food. "Unrefined" sugar (honey, evaporated cane juice, etc) is also very concentrated and is likely to contribute to the same problems as refined sugar.

========
http://www.springerlink.com/content/q61m05t142208891/

休士頓 m.d. Anderson 的相關連結

豆漿對於癌症的幫助
要從 phytochemicals 說起
總之結論是
依據理論上(theoretical 而已, 未必正確?) 以及 統計上來說
可以幫助 降低 攝護腺癌 以及 乳癌 (prostate cancer, breast cancer)

=============
另外 牛奶 可能性的會導致 乳癌 攝護腺癌

=============
anyway .... 總之

11 裡面的
A 是半對半錯
(糖的確是提供癌細胞養分, 但是糖也提供了所有細胞養分)
(主要原因 是簡單糖 會促成癌細胞滋長)
(而蜂蜜則是"天然的"簡單糖, 糖粉是"加工的"簡單糖, 都對有癌症的人不好)
另外海鹽 跟 加工鹽 與癌症的關係 網路上找不到相關資訊
(並沒有 "天然"就比較好, "加工"就比較不好 的這種說法)
我想原本寫這封信的人 這樣寫很有問題......
BC 應為正確 不過重點在於 對什麼癌症 不是通通有效
D 則是需要驗證, + 看情況
E 則是未必如此 也需要驗證

rural 發表於 7:35 AM | 靜態連結 | 迴響留言 | 引用列表 | 觀看 (3039)

星期四, 十二月 20, 2007
聽我媽又再轉述 新聞 關於扁想 拉榮民的票
可記得不久前 卻是扁 不斷的想剝奪榮民們的福利 ?
個人覺得 國人應對 榮民有些 應有的尊重才是
即使是被逼 非自願
又或是自願
榮民們都對國家付出很多貢獻
有多少人 願以自己性命危險 來為國家付出 保衛國家 爭取國民安全 ?
又有多少人 是非自願 但依然 以自己的性命危險 來做同樣的事情 ?

anyway..
本來有些想說的,忽然間又不想說了

總之
人還是 知足 感恩些的好...
rural 發表於 1:50 PM | 靜態連結 | 迴響留言 | 引用列表 | 觀看 (1870)

星期六, 十一月 24, 2007
今天在 shirt.woot.com 看到了一個 真有意思的設計
真是帥爆了
有夠 classic ... XD



怎講 算是 現代藝術吧 :)
我真是 超愛這個 Design 的



話說 圖片上
寫的字 也很有意思

Dissipate / Consume / Squander / Buy / Waste / Upgrade

More

Waste / Upgrade

比如說 Consume more waste , Buy more upgrade, Upgrade more, Waste more

其實涵意滿深的
不是 單單說字面上 (我想 字面上 只是 附加的意思而已)
而是 trademark 跟 一家公司間的關係
甚至於 在一家公司成名後 重點根本不在原本字面上是什麼意思了
而變成是 字型

相同的字型 樣式 不管套上什麼內容 都變成了一樣了

至於 字面上的意義
我覺得是 設計者 故意 惡搞
其實也不是惡搞 而是發人醒思
她用這些 字 湊成的意思
不外乎是說 花多點錢 浪費多點錢 去買多點東西
跟 原本 該公司擁有的 文字 是 完全的不同
可是卻 依然令人 聯想到 那些公司

總之
作者是 故意要 讓看到的人 把 那些公司 與 浪費錢 連上關係
還是想要 讓人們清醒說 原來都在浪費錢
一個一個 mark 下面 隱藏的 都是 相似的 idea

anyway ....
我很喜歡 這個設計
她的內容 個人覺得意義很深
可是不太知道 要怎樣 表達出來 讓大家也感受一下
哈哈
國文造詣太差吧
oh well ... :) hope you guys liked it ^^
rural 發表於 3:07 PM | 靜態連結 | 迴響留言 | 引用列表 | 觀看 (2570)

阿哈哈哈
今天才發現
已經是 11 月 2x 日了

我居然 錯過了 我前女友的生日
而且完全沒有想起來
真是帥呆了

不過相對的 我也把我爸生日忘了 - -
看來似乎是 我對於生日 非常不敏感
而不是 真的忘了... Orz ..
anyway ... 也算是 值得 亂七八糟 慶祝一下的就是了

rural 發表於 5:00 AM | 靜態連結 | 迴響留言 | 引用列表 | 觀看 (2004)

星期一, 十一月 19, 2007
....
我知道 雖然這新聞 很久了
我到今天才知道

可是 這真是 太 OOO XXX 了
http://www.youtube.com/watch?v=WZdPVTjt9wc


http://transcripts.cnn.com/TRANSCRIPTS/0705/24/ng.01.html
"Her father, a would-be minister, becomes agitated when the baby cries, throwing her first onto the bed, placing her second in the hotel refrigerator, third in the hotel room safe, then ultimately into the microwave and turns it on. And tonight, instead of protecting the baby girl, the mom defends her husband claiming the devil is responsible. She wants him free tonight. And they both want the baby back."
"His wife unloaded their luggage from the car, the baby crying. Nineteen-year-old Joshua Mauldin picks up 2-month old Eva Marie (ph), throws her onto the bed, punches her in the groin, then puts her in the hotel room safe, next the refrigerator, and finally the microwave, turning it on."

根據新聞報導
首先 父親 先把小孩(女孩) *丟* 到床上
猛 *打* 小孩 鼠谿部
然後 把小孩 放到 旅館 的 *保險箱* 關上門
之後 又把小孩 放到 *冰箱*
最後又 放到 *微波爐* 裡

根據 "不明來源"
http://www.huliq.com/22492/father-19-microwaved-2-month-old-baby
父親 供稱 都只有(冰箱,保險箱) 五秒鐘 而微波爐是 十秒鐘
可是警察說 有十分鐘

Texas Man Pleads Insanity for Burning Baby Daughter in Microwave
http://www.foxnews.com/story/0,2933,303736,00.html

State takes custody of microwave baby
http://www.khou.com/topstories/stories/khou070517_jj_microwavebaby.7a6cdced.html

現在 居然想要 求以 精神狀態 瘋狂 來免除罪刑

同時 據稱 小孩在微波爐裡時 母親是站在 父親旁邊的
而母親居然 替 父親 辯護 說是 魔鬼讓父親 這樣做的
同時 還想要拿回 小孩的 監護權
並替小孩的父親辯護
要求法院開釋父親 然後 才能 *一家人團聚* !!!???
rural 發表於 12:42 PM | 靜態連結 | 迴響留言 | 引用列表 | 觀看 (2029)

前不久 跟我哥女友隨便亂聊
忽然想到 以前曾經思考過的 類比電腦
前幾天看到一篇新聞 說 有人 用人腦 算 兩百位數的 十三次方根
在 7x 秒內算出 該說是厲害呢 還是怎樣
電腦想必 算不出來吧
不過如果有人 特別去 研究 13 方根 的 pattern
或許電腦也能很快算出??

不過想想 就想到了
如果真有類比電腦 會是怎樣的情況呢 ?
不是講 傳統的 類比電腦 而是 類似 人腦等的
接收類比訊號
個人推估是 類比電腦 將會 可以 很快速的 處理類比訊號 可是卻無法 處理數位
因為如果要 處理數位 比須先做訊號轉換 然後 處理結束後 還得將訊號 轉回數位
總之 就有點像人類一樣
雖然可以 *讀* 類比訊號非常快
可是 卻只能 用一定速度 分辨 *字母*(數位訊號)
然後 輸出時 也只能 用一定速度 輸出 (數位訊息)*寫字*

http://www.stanford.edu/class/ee368b/Handouts/09-HumanPerception.pdf

總之呢
眼睛的訊號 可以說算是 類比吧
不過 老實說 個人不太清楚 到底 訊號是成什的 format ...
是只有單單一個 impulse + magnitude.. 還是 impulse + magnitude + waveform ....
also ... 訊號 是否有被 結合 還是 1 cone/rod vs 1 axon/optic nerve ...


反正 亂亂寫 亂亂想

總的說 其實那也不該叫電腦了
該叫 ... 生化腦?
不知哪天會出現 生化腦...


oh 對了
聽到我媽說 美國發生一個案件
將小孩放到 微波爐裡
我 OO 她 XXX 的

恩 FF 的 hotkey 不能 disable 真是一大敗筆
rural 發表於 12:04 PM | 靜態連結 | 迴響留言 | 引用列表 | 觀看 (2065)

最近有些無聊
讀了本小說後 開始發懶
除了設計 cpu 外平時實在沒啥事情作
總之 看到了些 好玩的 有趣的
順便貼上來

AIDS Awareness!?
http://www.bag.admin.ch/hiv_aids/00833/index.html?lang=en&bild=27424lol

the world's only all-glass undersea restaurant.
http://www1.hilton.com/en_US/hi/hotel/MLEHITW-Hilton-Maldives-Resort-Spa-Rangali-Island/dining.do


德國天鵝明星 Petra
http://www.spiegel.de/international/0,1518,456656,00.html
rural 發表於 7:17 AM | 靜態連結 | 迴響留言 | 引用列表 | 觀看 (2225)

星期三, 十一月 14, 2007
O 妳個 X ... -_-
rural 發表於 3:36 PM | 靜態連結 | 關閉迴響 | 觀看 (20945)

星期三, 十月 17, 2007
===============
http://en.wikipedia.org/wiki/Silicon_germanium
SiGe allows CMOS logic to be integrated with heterojunction bipolar transistors, making it suitable for mixed-signal circuits. Heterojunction bipolar transistors have higher forward gain and lower reverse gain than homojunction bipolar transistors. This translates into better low current and high frequency performance. Being a heterojunction technology, the opportunity for band gap tuning exists which has normally been available only to compound semiconductors. Silicon Germanium-on-insulator (SGOI) is a technology similar to the Silicon-On-Insulator (SOI) technology currently employed in computer chips. SGOI increases the speed of the transistors inside microchips by stretching the space between the atoms, which forces the electricity to travel faster.
===============
http://www.theregister.co.uk/2004/04/20/amd_strained_silicon/
Intel already uses strained silicon in its 90nm process, which debuted with the launch of 'Prescott' Pentium 4 desktop CPUs in February. The technique works by adding a layer of silicon over a layer of silicon germanium (SiGe). The top layer's silicon atoms align themselves with those in the SiGe layer's wider-spaced crystal lattice, pulling them apart. Wider spaced silicon atoms make for a smoother flow of electrons between them, improving the material's electrical properties.

Adding that SiGe layer into an existing fabrication process is tricky - it's almost certainly one of the reasons Intel took longer than planned to roll out its 90nm chips.

===============
http://www.theregister.co.uk/2003/09/09/ibm_boffins_boost_chip_performance/
The strained silicon technique - currently being used by Intel to make its upcoming 90nm processors, Prescott and Dothan - improves the electrical efficiency of on-chip circuits by stretching a layer of silicon over a layer of silicon germanium (SiGe). The top layer's silicon atoms align themselves with those in the SiGe layer's wider-spaced crystal lattice, stretching them apart. This improves the flow of electrons through the 'strained' silicon layer.

That, in turn, yields a 20-30 per cent improvement in circuit performance, said IBM, but adding the SiGe layer means the circuits are harder to make and tricky to integrate into existing fabrication processes. That's probably why Intel waited until moving to 90nm before implementing the technique.

To avoid the implementation issues, IBM tried using its established SOI technology in place of SiGe. IBM uses an SiGe layer to strain the silicon lattice, but removes it before fabrication, after applying the strained silicon onto the insulator. The upshot: it gains benefits of strained silicon using what is essentially its standard SOI process. By removing the SiGe layer, it doesn't have to integrate that material into the chip fabrication process per se. It calls the new technique, Strained Silicon Directly on Insulator (SSDOI).
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http://www.amdboard.com/65nm_120605.html
The companies announced that they have successfully combined embedded Silicon Germanium (e-SiGe) with Dual Stress Liner (DSL) and Stress Memorization technology (SMT) on Silicon-On-Insulator (SOI) wafers, resulting in a 40 percent increase in transistor performance compared to similar chips produced without stress technology, while controlling power consumption and heat dissipation. The new process technologies reduce interconnect delay through the use of lower dielectric constant (lower-K) insulators, which can improve overall product performance and lower power consumption. In addition, the new technologies have shown ability to be manufactured at the 65nm generation and scaleable for use in future generations.
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http://www.tomshardware.com/forum/191593-28-issue-65nm-shrink
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http://investorshub.advfn.com/boards/read_msg.asp?message_id=21353453
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http://www.commsdesign.com/story/OEG20020915S0001
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http://www.realworldtech.com/page.cfm?ArticleID=RWT121303010053&p=4
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IBM 500GHz SiGe
http://www.eetimes.com/news/semi/showArticle.jhtml?articleID=189500692
http://arstechnica.com/news.ars/post/20060622-7117.html
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40G photodetector: The other end of the link
http://blogs.intel.com/research/2007/09/40g_photodetector.html
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SSOI
http://www.eetimes.com/story/OEG20031222S0024
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Stretching silicon's lifespan
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http://www.theinquirer.net/en/inquirer/news/2006/03/08/not-all-cpus-are-created-equal
http://www.theinquirer.net/en/inquirer/news/2006/03/18/amd-fab-36-starts-to-ramp
http://www.theinquirer.net/en/inquirer/news/2006/06/09/amd-waits-for-65nm-to-crank-up-the-megahurts
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http://www.eetimes.com/showArticle.jhtml;jsessionid=AXIAAGFJ4LZC2QSNDLQSKICCJUNN2JVN?articleID=196701745
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