Desparing
星期天, 一月 20, 2008
CoQ10

既然之前寫了一篇跟癌症相關的

那就順道把之前約略 整理 + 篩選 與 CoQ10 相關的東西一起放上來吧

剛好也是 整理 寫給我媽的....至於她有沒有看嘛... LOL 大概不會吧 (因為都是英文)

內容我都有讀過 並且已經篩選過的... 大多都是有真實證據 或是 大學/醫院 的研究報告 

反正有興趣的人 就自己讀吧  有問題也可以問我

個人是不打算翻譯那些內容的 ... 畢竟那又不是我的職業 我也賺不到錢 說了也未必有人聽 :)

寫了對整個 man kind 甚至於地球 也未必有幫助 

所以 自己讀吧!

 

CoQ10 根據某些來源指出

有降血壓 防癌 預防心臟病 甚至更多其他功能

題外話: milk thistle 則有幫助肝功能 甚至於 預防肝癌的可能性....有機會在貼

==============Use of CoQ10==============

Uses based on tradition or theory

Abnormal heart rhythms, amyotrophic lateral sclerosis (ALS), antioxidant, asthma, atherosclerosis, Bell's palsy, blood flow disorders, breathing difficulties, cancer, cerebellar ataxia, chronic fatigue syndrome, chronic obstructive pulmonary disease (COPD), deafness, gingivitis, hair loss (and hair loss from chemotherapy), heart irregular beats, hepatitis B, high cholesterol, immune system diseases, infertility, insomnia, kidney failure, leg swelling (edema), life extension, liver enlargement or disease, lung cancer, lung disease, macular degeneration, MELAS syndrome, metastatic disease, MIDD (maternally inherited diabetes mellitus and deafness), muscle wasting, nutrition, obesity, Papillon-Lefevre Syndrome, physical performance, prevention of muscle damage from "statin" cholesterol-lowering drugs, psychiatric disorders, QT-interval shortening; reduction of phenothiazine drug side effects, reduction of tricyclic antidepressant (TCA) drug side effects, stomach ulcer, swelling.

Source: Coenzyme Q10 @ MayoClinic.com
(The website also includes a list of detailed evidence and its credibility grading.)

===========Cancer Related================

Coenzyme Q 10 is a compound that is made naturally in the body. The body uses it for cell growth and to protect cells from damage that could lead to cancer.

Animal studies have shown that coenzyme Q10 helps the immune system work better and makes the body better able to resist certain infections and types of cancer.

Clinical trials have shown that coenzyme Q10  helps protect the heart from the damaging side effects of doxorubicin, a drug used to treat cancer.

In 3 small studies of coenzyme Q10 in breast cancer patients, some patients appeared to be helped by the treatment. Weaknesses in study design and reporting, however, made it unclear if benefits were caused by the coenzyme Q10 or by something else.

Coenzyme Q10 may not mix safely with other treatments. It is important that patients tell their health care providers about all therapies they are currently using or thinking of using.

Coenzyme Q10 has not been carefully tested to see if it is safe and effective. Because coenzyme Q10 is sold as a dietary supplement rather than a drug, it is not regulated by the US Food and Drug Administration.

Source: Coenzyme Q10 @ National Cancer Institute

===========================

CoQ10 @ Congestive Heart Failure patients ( CHFpatients.com)
(no evidence for improvement, however, sick hearts do have Less CoQ10)

===========================

Coenzyme Q10 may be indicated in cardiovascular disease, particularly in congestive heart failure. It may also be indicated to correct reduced blood levels of CoQ10 that result from the use of HMG-CoA reductase inhibitors used to treat elevated cholesterol levels. It also appears to have usefulness in the management of periodontal disease in some. There is far less evidence to support claims that it has positive effects in cancer, muscular dystrophy and immune dysfunction. Similarly, there is as yet no reliable evidence that it can inhibit obesity or enhance athletic performance.

Coenzyme Q10 (CoQ10) @ Physicians Desk Reference ( PDRhealth.com)

==============
Huntington's Disease ===============

In April 2006, veteran researcher R. Ferrante and collaborators reported results from a thorough and significant study of CoQ-10 "Dose ranging and efficacy study of high-dose coenzyme Q-10 formulations in Huntington's disease mice" (Biochem Biophys Acta. 2006 Apr 17)). In this article, the authors find that more is better. The HD mice treated with high dose CoQ-10 had survival benefit of 25.3%, which is significantly higher than 13-14.5% benefit shown in earlier studies using lower doses. (Ferrante 2002, 2005).

CoQ10: more is best @ the
Huntington's Disease light house

===============CoQ10's Use on Drug=================

specific coenzyme Q-10 products have been given orphan drug status in the United States. An orphan drug has received FDA approval because it shows effectiveness for treating severe or rare diseases that usually have few other treatment options.

In the United States, designated coenzyme Q10 products are used to treat Huntington's disease, childhood heart failure, and rare, inherited disorders of red blood cell formation or defects in mitochondria, which are tiny structures within body cells.

CoQ10 @ Drug Digest (use of CoQ10)

===================================

Scientists believe CoQ10 is an antioxidant (a compound that blocks activated oxygen molecules, known as free radicals, that can damage cells), and that it may also have an effect on the immune system. Some studies have suggested that deficiencies of CoQ10 may contribute to certain diseases such as cancer.

Coenzyme Q10 @ American Cancer Society (Breast Cancer)

Note: Information on Antioxidant & Free Radicals

===============History========
============

Coenzyme Q was first discovered by professor Fred L. Crane and colleagues at the University of Wisconsin-Madison Enzyme Institute in 1957. In 1958, its chemical structure was reported by Professor Karl Folkers and coworkers at Merck. For his discovery of the significant part played by CoQ10 in energy production, the British scientist Peter D. Mitchell was awarded the Nobel Prize for chemistry in 1978.

Coenzyme Q10 @ Wikipedia (General Information)

===================================

Introduction to Coenzyme Q10  By PETER H. LANGSJOEN, M.D., F.A.C.C.

================================

Information on CoQ10 (Researches) @ University of Washington (General Information)

John T. A. Ely had included 19 selected PubMed research abstracts.
Abstract Titles :
Effective and safe therapy with coenzyme Q10 for cardiomyopathy.
    --
Clinical responses on therapy with CoQ10 appear maximal with blood levels of approx. 2.5 micrograms CoQ10/ml and higher during therapy.

Response of patients in classes III and IV of cardiomyopathy to therapy in a blind and crossover trial with coenzyme Q10.
    --
These patients, steadily worsening and expected to die within 2 years under conventional therapy, generally showed an extraordinary clinical improvement, indicating that CoQ10 therapy might extend the lives of such patients.This improvement could be due to correction of a myocardial deficiency of CoQ10 and to enhanced synthesis of CoQ10-requiring enzymes.

Effective treatment with coenzyme Q10 of patients with chronic myocardial disease.
    --
Eighteen patients reported improvement in activity tolerance with oral CoQ10 replacement therapy.

Therapy with coenzyme Q10 of patients in heart failure who are eligible or ineligible for a transplant.
   --
The marked improvement is based upon correcting myocardial deficiencies of CoQ10 which improve mitochondrial bioenergetics and cardiac performance.

A six-year clinical study of therapy of cardiomyopathy with coenzyme Q10.
   --
One hundred and forty-three cases of chronic, stable, non- secondary, non-hypertrophic cardiomyopathy were given 100 mg of coenzyme Q10** orally in addition to their conventional medical programme in an open-label long-term study. Survival figures were encouraging with an 11.1% mortality in 12 months and 17.8% mortality in 24 months.

Pronounced increase of survival of patients with cardiomyopathy when treated with coenzyme Q10 and conventional therapy.
   --
The improved cardiac function and pronounced increase of survival show that therapy with CoQ10 is remarkably beneficial due to correction of CoQ10 deficiency in mechanisms of bioenergetics.

Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases.
   --
The numerous metastases in the liver of a 44-year-old patient "disappeared," and no signs of metastases were found elsewhere. A 49-year-old patient, on a dosage of 390 mg of vitamin Q10, revealed no signs of tumor in the pleural cavity after six months, and her condition was excellent. A 75-year-old patient with carcinoma in one breast, after lumpectomy and 390 mg of CoQ10, showed no cancer in the tumor bed or metastases. Control blood levels of CoQ10 of 0.83-0.97 and of 0.62 micrograms/ml increased to 3.34-3.64 and to 3.77 micrograms/ml, respectively, on therapy with CoQ10 for patients A-MRH and EEL.

Apparent partial remission of breast cancer in 'high risk' patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10.
  --

Partial and complete regression of breast cancer in patients in relation to dosage of coenzyme Q10.
The activities of coenzyme Q10 and vitamin B6 for immune responses.
Survival of cancer patients on therapy with coenzyme Q10.
Survival effect of coenzyme Q10 and naloxone on experimental stroke gerbils.
Possible use of coenzyme Q10 in acute cerebral disease.
Hemorrhagic Stroke in Human Pretreated with Coenzyme Q10: Exceptional Recovery as Seen in Animal Models.
Overview of the use of CoQ10 in cardiovascular disease.
Lethal Candidiasis: An Interpretive Review with Emphasis on Neglected, Safe, Effective, Inexpensive Therapies
A brief update on ubiquinone (Coenzyme Q10).
Does gastrointestinal Candida albicans prevent ubiquinone absorption?


=================================

Possible Health Benefits of Coenzyme Q10 @ Oregon State University (General Information)

Study Suggests Coenzyme Q10 Slows Functional Decline in Parkinson's Disease @ National Institute of Neurological Disorders and Stroke (Parkinson's Disease)

Small Doses of Coenzyme Q10 Does Not Improve Parkinson's Disease Symptoms @ ScienceDaily.com

 

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